Volume 2 Supplement 3
Stable disease after high dose interleukin-2 (HD IL-2) immunotherapy: observations on long term survival and clinical benefit of additional HD IL-2
© Kaufman et al.; licensee BioMed Central Ltd. 2014
Published: 6 November 2014
Unlike chemotherapy and targeted therapies, immunotherapeutics have the unique potential to achieve long lasting durable responses in cancer. The continual homeostasis between the immune system and the tumor requires constant immune pressure, and tipping the balance toward the immune system using immunotherapy may be important. Registries such as PROCLAIMSM provide data which may guide the optimal sequencing of therapies and/or prioritization of randomized clinical trials .
We conclude that stable disease is durable and should be considered a valuable end point. Consolidation of this response with additional HD IL-2 treatment following SD may be important.
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