Volume 3 Supplement 1

Abstracts of the Breast Cancer Immunotherapy Symposium (BRECIS): Sidra Symposia Series

Open Access

Towards targeting PD-1/PD-L1 axis in breast cancer, pre-clinical data

  • Hazem Ghebeh1,
  • Dilek Colak2,
  • Asma Tulbah3 and
  • Abdullah Alsuliman1
Journal for ImmunoTherapy of Cancer20153(Suppl 1):P7

https://doi.org/10.1186/2051-1426-3-S1-P7

Published: 14 August 2015

PD-L1 is a ligand that upon binding to its receptor (PD-1) on T-cells leads to T-cell anergy/and or apoptosis [1, 2]. We have shown that PD-L1 is expressed in breast cancer where its expression correlates with estrogen receptor (ER) negativity [3]. To understand the mechanism of the constitutive expression of PD-L1 in tumor cells of ER negative cells we used gene-in and out approach, large scale bioinformatics and immunohistochemistry. We have demonstrated that epithelial to mesenchymal transition (EMT) upregulates PD-L1 expression while cells expressing ER downregulates PD-L1, in parallel with reversal of EMT process. Bioinformatics analysis of gene expression signatures of breast tumors showed a significant correlation between EMT score and PD-L1 mRNA expression. Strikingly, very strong association were found between PD-L1 expression and claudin low breast cancer, a subset of breast cancer known to have high EMT score. In conclusion, we have characterized the expression of PD-L1 in breast cancer and we have demonstrated a strong association between PD-L1 expression, EMT status and claudin-Low breast cancer. Our finding will be essential for choosing the appropriate subset of breast cancer patients that will likely benefit from anti-PD-L1 targeted therapy and understand biological changes upon anti-PD-L1 therapy.

Authors’ Affiliations

(1)
Stem Cell & Tissue Re-engineering Program, King Faisal Specialist Hospital and & Research Centre
(2)
Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital & Research
(3)
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre

References

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Copyright

© Ghebeh et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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