Clinical/Translational Cancer Immunotherapy

Section edited by F. Stephen Hodi, Jr., MD

First-in-man clinical trials, phase II/III clinical studies, immune monitoring investigations, tumor microenvironment, host genetics and clinical outcome, combination therapies, and cell therapies.

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  1. Research article

    A retrospective analysis of High-Dose Interleukin-2 (HD IL-2) following Ipilimumab in metastatic melanoma

    High dose interleukin-2 (HD IL-2) can induce durable responses in a subset of patients leading to long-term survival. Immune checkpoint blockade (ICB) has demonstrated similarly durable responses in a larger p...

    Elizabeth I. Buchbinder, Anasuya Gunturi, Jessica Perritt, Janice Dutcher, Sandra Aung, Howard L. Kaufman, Marc S. Ernstoff, Girald P. Miletello, Brendan D. Curti, Gregory A. Daniels, Sapna P. Patel, John M. Kirkwood, Sigrun Hallmeyer, Joseph I. Clark, Rene Gonzalez, John M. Richart…

    Journal for ImmunoTherapy of Cancer 2016 4:52

    Published on: 20 September 2016

  2. Research article

    Phase II study of vemurafenib followed by ipilimumab in patients with previously untreated BRAF-mutated metastatic melanoma

    Ipilimumab (IPI), an anti-CTLA-4 antibody, and vemurafenib (VEM), a BRAF inhibitor, have distinct mechanisms of action and shared toxicities (e.g., skin, gastrointestinal [GI] and hepatobiliary disorders) that...

    Asim Amin, David H. Lawson, April K.S. Salama, Henry B. Koon, Troy Guthrie, Sajeve S. Thomas, Steven J. O’Day, Montaser F. Shaheen, Bin Zhang, Stephen Francis and F. Stephen Hodi

    Journal for ImmunoTherapy of Cancer 2016 4:44

    Published on: 16 August 2016

  3. Research article

    A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma

    Preclinical studies have shown synergy between radiation therapy and immunotherapy. However, in almost all preclinical models, radiation is delivered in single doses or short courses of high doses (hypofractio...

    Todd Crocenzi, Benjamin Cottam, Pippa Newell, Ronald F. Wolf, Paul D. Hansen, Chet Hammill, Matthew C. Solhjem, Yue-Yun To, Amy Greathouse, Garth Tormoen, Zeljka Jutric, Kristina Young, Keith S. Bahjat, Michael J. Gough and Marka R. Crittenden

    Journal for ImmunoTherapy of Cancer 2016 4:45

    Published on: 16 August 2016

  4. Research article

    Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab

    We have previously investigated neoadjuvant ipilimumab (ipi) for patients with locally/regionally advanced melanoma. That initial assessment of peripheral blood mononuclear cells (PBMC) showed a significant in...

    Janet Retseck, Robert VanderWeele, Hui-Min Lin, Yan Lin, Lisa H. Butterfield and Ahmad A. Tarhini

    Journal for ImmunoTherapy of Cancer 2016 4:38

    Published on: 21 June 2016

  5. Research article

    Progression-free and overall survival in ovarian cancer patients treated with CVac, a mucin 1 dendritic cell therapy in a randomized phase 2 trial

    CAN-003 was a randomized, open-label, Phase 2 trial evaluating the safety, efficacy and immune outcomes of CVac, a mucin 1 targeted-dendritic cell (DC) treatment as a maintenance therapy to patients with epith...

    H. J. Gray, B. Benigno, J. Berek, J. Chang, J. Mason, L. Mileshkin, P. Mitchell, M. Moradi, F. O. Recio, C. M. Michener, A. Alvarez Secord, N E. Tchabo, J. K. Chan, J. Young, H. Kohrt, S. E. Gargosky…

    Journal for ImmunoTherapy of Cancer 2016 4:34

    Published on: 21 June 2016

  6. Short report

    Concurrent SPECT/PET-CT imaging as a method for tracking adoptively transferred T-cells in vivo

    The ability of T-cells to traffic to and penetrate tumors impacts the clinical efficacy of T-cell therapy therefore methods to track transferred T-cells in vivo are needed. In this preliminary report, we evalu...

    Sasha E. Stanton, Janet F. Eary, Edmond A. Marzbani, David Mankoff, Lupe G. Salazar, Doreen Higgins, Jennifer Childs, Jessica Reichow, Yushe Dang and Mary L. Disis

    Journal for ImmunoTherapy of Cancer 2016 4:27

    Published on: 17 May 2016

  7. Research article

    Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

    Glioblastoma (GBM) is a poorly immunogenic neoplasm treated with focused radiation. Immunotherapy has demonstrated synergistic survival effects with stereotactic radiosurgery (SRS) in murine GBM. GITR is a co-...

    Mira A. Patel, Jennifer E. Kim, Debebe Theodros, Ada Tam, Esteban Velarde, Christina M. Kochel, Brian Francica, Thomas R. Nirschl, Ali Ghasemzadeh, Dimitrios Mathios, Sarah Harris-Bookman, Christopher C. Jackson, Christina Jackson, Xiaobu Ye, Phuoc T. Tran, Betty Tyler…

    Journal for ImmunoTherapy of Cancer 2016 4:28

    Published on: 17 May 2016

    The Erratum to this article has been published in Journal for ImmunoTherapy of Cancer 2016 4:74

  8. Research article

    Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer

    The currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive ultrasound-guided nodal injections or microsurgical lymphati...

    Michal Radomski, Herbert J. Zeh, Howard D. Edington, James F. Pingpank, Lisa H. Butterfield, Theresa L. Whiteside, Eva Wieckowski, David L. Bartlett and Pawel Kalinski

    Journal for ImmunoTherapy of Cancer 2016 4:24

    Published on: 19 April 2016

  9. Research article

    Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

    We conducted a phase I study with a granulocyte macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with solid tumors refractory to available treatments. The ob...

    Tuuli Ranki, Sari Pesonen, Akseli Hemminki, Kaarina Partanen, Kalevi Kairemo, Tuomo Alanko, Johan Lundin, Nina Linder, Riku Turkki, Ari Ristimäki, Elke Jäger, Julia Karbach, Claudia Wahle, Matti Kankainen, Charlotta Backman, Mikael von Euler…

    Journal for ImmunoTherapy of Cancer 2016 4:17

    Published on: 15 March 2016

  10. Research article

    Systemic versus local responses in melanoma patients treated with talimogene laherparepvec from a multi-institutional phase II study

    We previously reported that talimogene laherparepvec, an oncolytic herpes virus encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), resulted in an objective response rate of 26 % in patients wi...

    Howard L. Kaufman, Thomas Amatruda, Tony Reid, Rene Gonzalez, John Glaspy, Eric Whitman, Kevin Harrington, John Nemunaitis, Andrew Zloza, Michael Wolf and Neil N. Senzer

    Journal for ImmunoTherapy of Cancer 2016 4:12

    Published on: 15 March 2016

  11. Research article

    Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack

    The angiopoietin/Tie2 pathway is an attractive target for cancer therapy due to its well-known role in regulating angiogenesis. Trebananib, a recombinant peptide-Fc fusion protein, or peptibody, that binds to ...

    Italia Grenga, Anna R. Kwilas, Renee N. Donahue, Benedetto Farsaci and James W. Hodge

    Journal for ImmunoTherapy of Cancer 2015 3:52

    Published on: 17 November 2015

  12. Research article

    Cetuximab ameliorates suppressive phenotypes of myeloid antigen presenting cells in head and neck cancer patients

    Myeloid-derived suppressor cells (MDSC) and M2 monocytes/macrophages are two types of suppressive myeloid antigen presenting cells that have been shown to promote tumor progression and correlate with poor prog...

    Jing Li, Raghvendra M. Srivastava, Abhinav Ettyreddy and Robert L. Ferris

    Journal for ImmunoTherapy of Cancer 2015 3:54

    Published on: 17 November 2015

  13. Research article

    Survival with AGS-003, an autologous dendritic cell–based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): Phase 2 study results

    AGS-003 is an autologous immunotherapy prepared from fully matured and optimized monocyte-derived dendritic cells, which are co-electroporated with amplified tumor RNA plus synthetic CD40L RNA. AGS-003 was eva...

    Asim Amin, Arkadiusz Z Dudek, Theodore F Logan, Raymond S Lance, Jeffrey M Holzbeierlein, Jennifer J Knox, Viraj A Master, Sumanta K Pal, Wilson H Miller, Lawrence I Karsh, Irina Y Tcherepanova, Mark A DeBenedette, W Lee Williams, Douglas C Plessinger, Charles A Nicolette and Robert A Figlin

    Journal for ImmunoTherapy of Cancer 2015 3:14

    Published on: 21 April 2015

  14. Research article

    Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction

    BCG is a prototypal cancer immunotherapeutic factor currently approved of bladder cancer. In attempt to further enhance the effectiveness of immunotherapy of bladder cancer and, potentially, other malignancies...

    Ravikumar Muthuswamy, Liwen Wang, Jamie Pitteroff, Jeffrey R Gingrich and Pawel Kalinski

    Journal for ImmunoTherapy of Cancer 2015 3:6

    Published on: 24 March 2015

  15. Research article

    Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application

    Virus-specific T-cells (VSTs) proliferate exponentially after adoptive transfer into hematopoietic stem cell transplant (HSCT) recipients, eliminate virus infections, then persist and provide long-term protect...

    Jiali Sun, Leslie E Huye, Natalia Lapteva, Maksim Mamonkin, Manasa Hiregange, Brandon Ballard, Olga Dakhova, Darshana Raghavan, April G Durett, Serena K Perna, Bilal Omer, Lisa A Rollins, Ann M Leen, Juan F Vera, Gianpietro Dotti, Adrian P Gee…

    Journal for ImmunoTherapy of Cancer 2015 3:5

    Published on: 18 February 2015

  16. Research article

    Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study

    Adrenocortical carcinoma (ACC) is a rare tumor in which prognostic factors are still not well established. Programmed Death Ligand-1 (PD-L1) expression in ACC and its association with clinico-pathological feat...

    André P Fay, Sabina Signoretti, Marcella Callea, Gabriela H Telό, Rana R McKay, Jiaxi Song, Ingrid Carvo, Megan E Lampron, Marina D Kaymakcalan, Carlos E Poli-de-Figueiredo, Joaquim Bellmunt, F Stephen Hodi, Gordon J Freeman, Aymen Elfiky and Toni K Choueiri

    Journal for ImmunoTherapy of Cancer 2015 3:3

    Published on: 17 February 2015

  17. Short report

    Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade

    Assessment of therapeutic activity of drugs blocking immune checkpoints such as CTLA-4 and PD-1/PD-L1 can be challenging, as tumors may seem to enlarge or appear anew before regressing, due to intratumoral inf...

    Evan J Lipson, Victor E Velculescu, Theresa S Pritchard, Mark Sausen, Drew M Pardoll, Suzanne L Topalian and Luis A Diaz

    Journal for ImmunoTherapy of Cancer 2014 2:42

    Published on: 16 December 2014

  18. Research article

    CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy

    Immunological quiescence in the central nervous system (CNS) is a potential barrier to immune mediated anti-tumor response. One suppressive mechanism results from the interaction of parenchyma-derived CD200 an...

    Christopher L Moertel, Junzhe Xia, Rebecca LaRue, Nate N Waldron, Brian M Andersen, Robert M Prins, Hideho Okada, Andrew M Donson, Nicholas K Foreman, Matthew A Hunt, Christopher A Pennell and Michael R Olin

    Journal for ImmunoTherapy of Cancer 2014 2:46

    Published on: 16 December 2014

  19. Research article

    Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome

    Investigate the tumor diameter and density changes in advanced melanoma patients treated with ipilimumab plus bevacizumab, compare response rates based on different response criteria, and study association bet...

    Mizuki Nishino, Anita Giobbie-Hurder, Nikhil H Ramaiya and F Stephen Hodi

    Journal for ImmunoTherapy of Cancer 2014 2:40

    Published on: 18 November 2014

  20. Research article

    Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells

    Adoptive T cell therapy represents an attractive modality for the treatment of patients with cancer. Peripheral blood mononuclear cells have been used as a source of antigen specific T cells but the very low f...

    Seth M Pollack, Robin L Jones, Erik A Farrar, Ivy P Lai, Sylvia M Lee, Jianhong Cao, Venu G Pillarisetty, Benjamin L Hoch, Ashley Gullett, Marie Bleakley, Ernest U Conrad, Janet F Eary, Kendall C Shibuya, Edus H Warren, Jason N Carstens, Shelly Heimfeld…

    Journal for ImmunoTherapy of Cancer 2014 2:36

    Published on: 14 October 2014

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