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Section edited by Christian Capitini, MD

Reaction to and/or perspectives on significant events in the field in the basic science area. May address a critical challenge, elaborate or extend a conversation of a focal article, provide an application of a theoretical perspective, or shed light on a particular issue in the field.

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  1. Content type: Hypothesis

    Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of indivi...

    Authors: Tolga Turan, Deepti Kannan, Maulik Patel, J. Matthew Barnes, Sonia G. Tanlimco, Rongze Lu, Kyle Halliwill, Sarah Kongpachith, Douglas E. Kline, Wouter Hendrickx, Alessandra Cesano, Lisa H. Butterfield, Howard L. Kaufman, Thomas J. Hudson, Davide Bedognetti, Francesco Marincola…

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:50

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  2. Content type: Commentary

    Immune checkpoint inhibitors have emerged as a promising therapeutic option for metastatic cancers. However, they have been associated with inflammatory adverse reactions in various organ systems. A recent art...

    Authors: Marc-Elie Nader, Jeffrey N. Myers and Paul W. Gidley

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:24

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  3. Content type: Commentary

    Inbred mice are the mainstay for preclinical cancer assessment of potential therapeutics, especially immune-based approaches. However, the use of young, lean, inbred mice housed under specific-pathogen-free co...

    Authors: William J. Murphy

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:88

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  4. Content type: Commentary

    The recent use of T cell-based cancer immunotherapies, such as adoptive T-cell transfer and checkpoint blockade, yields increasing clinical benefit to patients with different cancer types. However, decrease of...

    Authors: Sonia T. Chelbi and Greta Guarda

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:39

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  5. Content type: Commentary

    Mounting an immune response sufficient to eradicate a tumor is the goal of modern immunotherapy. Single agent therapies with checkpoint inhibitors or costimulatory molecule agonists are effective only for a sm...

    Authors: Stefanie N. Linch and William L. Redmond

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:31

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  6. Content type: Commentary

    The Common Rule is a set of ethical principles that provide guidance on the management of human subjects taking part in biomedical and behavioral research in the United States. The elements of the Common Rule ...

    Authors: Howard L. Kaufman, Lisa H. Butterfield, Pierre G. Coulie, Sandra Demaria, Robert L. Ferris, Jérôme Galon, Samir N. Khleif, Ira Mellman, Pamela S. Ohashi, Willem W. Overwijk, Suzanne L. Topalian and Francesco M. Marincola

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:37

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