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- Open Access
Prognosis of tumor infiltrating lymphocytes in operable tongue cancer patients
© Chen et al.; licensee BioMed Central Ltd. 2014
Published: 6 November 2014
The immune microenvironment is important to the pathophysiology of head and neck squamous cell carcinoma (HNSCC). Our aim was to investigate the prognostic significance of tumour-infiltrating lymphocytes (TILs) in operable tongue cancer patients treated with curative surgery and adjuvant radiotherapy with or without chemotherapy.
Patients and methods
The presence of CD3+, CD4+, CD8+ and FOXP3+ TILs in tumor tissues obtained from 93 patients during surgery were examined by immunohistochemistry. Correlation between clinicopathological features and TILs was investigated. The prognostic roles of TILs for local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), distant metastasis-free survival (DMFS) and overall survival (OS) were analyzed.
CD4+ TILs and its ratio to other TILs were inversely correlated with LVI. Higher CD4/CD3 ratio predicts better DMFS. Prognostic role of FOXP3 in RRFS was marginally significant and warrants further investigation.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.