You are viewing the site in preview mode

Skip to main content


Haplotypes of SNPs associated with COX-2 and their comparison with histopathological features of breast cancer patients


In breast cancer, increased cyclooxygenase-2 expressions is associated with poor prognosis. COX-2 expression influences production of pro-inflammatory prostaglandins. The present study investigated association between COX-2 promoter polymorphisms (rs689465, rs689466, rs20417) and histopathological features of breast cancer patients.


We selected 150 HER-2 amplification positive breast cancer patients from our previous case-control study. The participants were evaluated for histopathological features and genotyped for COX-2 SNPs. Comparisons of genotype data with histopathological characteristics were performed by chi square test. Logistic regression was applied for estimation of odd ratios. COX-2 protein level and other markers were assessed by immunohistochemical staining. Statistical analyses were performed using SPSS version 19.0 and p value was set at <0.05.


Our data showed that elevated COX-2 expression was significantly associated with HER-2 amplified tumours. In addition, a positive association between rs20417 (GC+CC) and estrogens receptor (OR: 0.383, 0.161-0.913, P: 0.030) and IDC tumour (OR: 0.264, 0.070-0.993, P: 0.049) was noted. Eight haplotypes were deduced and associations with tumour size (P: 0.030), HER-2 amplification (P: < 0.0001), ER positivity (P: 0.017) were observed.


Present study suggests that COX-2 expression and haplotypes of its associated SNPs should be considered for characterizing breast cancer prognosis.

Author information

Correspondence to Tariq Moatter.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark


  • Breast Cancer
  • Breast Cancer Patient
  • Promoter Polymorphism
  • Positive Breast Cancer
  • Cancer Prognosis