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  • Poster presentation
  • Open Access

Circulating immune cells in patients with surgically resected nonfunctional pancreatic neuroendocrine tumors

  • 1,
  • 1,
  • 1, 2,
  • 3,
  • 3,
  • 3,
  • 1, 2, 3,
  • 1, 2, 3 and
  • 1, 2, 3
Journal for ImmunoTherapy of Cancer20153 (Suppl 2) :P140

https://doi.org/10.1186/2051-1426-3-S2-P140

  • Published:

Keywords

  • Lymph Node
  • Immune Cell
  • Lymph Node Positivity
  • Neuroendocrine Tumor
  • Malignant Potential

Background

There is debate regarding whether surgical resection and/or lymphadenectomy are indicated for small nonfunctional pancreatic neuroendocrine tumors (PNETs). Myeloid cell population expansion in peripheral blood has been correlated with clinical stage of patients with solid tumors. We aim to determine if blood sampling can be used as a predictor of malignant potential in nonfunctional PNETs.

Methods

We prospectively measured cell counts in 29 patients with PNET using flow cytometry of fresh whole blood before and after surgery, including CD3+, CD8+, and CD4+ T cells; monocytes; and granulocytes. Correlations were sought with known clinical markers of malignant potential such as tumor size, grade, number of positive lymph nodes, and TNM stage using t-test and one-way ANOVA analysis (STATA Inc).

Results

In this small cohort of patients, there were no differences in circulating immune cell counts between patients with lymph node metastases versus those without, nor in patients with tumors > 2cm, nor in those patients with high grade tumors. Interestingly, patients with lymph node metastases had a significant decrease in number of circulating CD8+ T cells post operatively when compared to those with negative lymph nodes (p = 0.013). There was a similar decrease in monocyte count post operatively in patients with positive versus negative lymph nodes that did not reach significance (p = 0.056).

Conclusions

Our data do not provide evidence that circulating immune cell populations can be used as biomarkers of lymph node positivity or of malignant potential in PNET prior to resection.

Authors’ Affiliations

(1)
Providence Cancer Center, Portland, OR, USA
(2)
Earle A. Chiles Research Institute, Portland, OR, USA
(3)
The Oregon Clinic, Portland, OR, USA

Copyright

© Jutric et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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