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  • Poster presentation
  • Open Access

Sub-lethal ionizing radiation alters Foxp3 expression in CD4+ T regulatory (Treg) cells in vitro and in vivo

  • 1,
  • 1 and
  • 1
Journal for ImmunoTherapy of Cancer20153 (Suppl 2) :P269

https://doi.org/10.1186/2051-1426-3-S2-P269

  • Published:

Keywords

  • Public Health
  • Gene Expression
  • Treg Cell
  • Radiation Treatment
  • Cell Phenotype

The use of sub-lethal radiation has been shown to alter cell phenotype and gene expression. T regulatory (Treg) cells are phenotypically defined as being CD4+CD25+ Foxp3+ T cells and are known to suppress the function of CD8+ cytotoxic T lymphocytes (CTLs). Inhibiting the suppressive function of Treg cells allows for activation and proliferation of CD8+ CTLs. We examined the effects of sub-lethal radiation on Tregs 24- to 72-hrs post-treatment. We found that radiation treatment decreased the number of Treg cells however the total CD4+ T cell fraction remained unaltered. Our data suggests that the use of sub-lethal radiation can modulate the expression of Foxp3 in CD4+ Treg cells in vitro and in vivo. Moreover, the loss of Foxp3-mediated suppressive functions may be linked to increased CTL activity.

Authors’ Affiliations

(1)
GSU, Atlanta, GA, USA

Copyright

© Kumari et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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