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  • Poster presentation
  • Open Access

L-tyrosine is a promising cancer vaccine adjuvant

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  • 1,
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Journal for ImmunoTherapy of Cancer20153 (Suppl 2) :P440

https://doi.org/10.1186/2051-1426-3-S2-P440

  • Published:

Keywords

  • Murine Model
  • Antigen Presentation
  • Undesirable Effect
  • Cancer Vaccine
  • Imiquimod

The choice of adjuvants is critical for any vaccine whether prophylactic or therapeutic. Our group previously showed that incomplete Freund's adjuvant, commonly used in different cancer vaccine trials, had many undesirable effects on T cell trafficking and function which directly translates into poor anti-tumor efficacy in preclinical murine model. Switching from oil-based (IFA) to water based (saline) vaccine eliminates those undesirable effects but at the cost of low specific T cell number. We therefore screened for adjuvants capable of inducing high T cell number with superior function and trafficking to the tumor. Here, we show that L-tyrosine particle is a very promising adjuvant for peptide based cancer vaccine. In combination with covax (including IL-2, anti-CD40 and imiquimod, a TLR-7 agonist), particle based L-tyrosine vaccine induces superior tumor specific CD8 T cell response, in terms of T cell number and function, resulting in remarkable anti-tumor efficacy. Mechanistic study shows that L-tyrosine particle extends antigen presentation time which is long enough for optimal T cell priming but not too long to induce a “grave yard” for the primed T cells. Understanding how the L-tyrosine particle works will provide more rationale for future vaccine adjuvant design.

Authors’ Affiliations

(1)
University of Texas - MD Anderson Cancer Center, Houston, TX, USA

Copyright

© Khong et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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