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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient

Fig. 4

Analysis on tumor infiltrating human T cells after adoptive transfer to mice bearing NCI-H630 tumors. a mRNA expression of CD3, CD4, CD8 and CX3CR1 (human specific primers) from tumors of mice receiving eGFP-T cells (white bars) or CX3CR1-eGFP T cells (black bars), triplicates +/−SEM. b Immunohistochemical analysis of CD3 expression in paraffin embedded tumors after adoptive T cell transfer; c CD3 stain positive area quantified using image pro analysis software. d Weight of tumors after adoptive transfer of eGFP/CX3CR1-eGFP lymphocytes in mice (6–7 mice per group). *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001 for difference between eGFP and CX3CR1-eGFP expressing T lymphocytes (Student’s t test)

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