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Fig. 4 (abstract P166). | Journal for ImmunoTherapy of Cancer

Fig. 4 (abstract P166).

From: 32nd Annual Meeting and Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2017): Part One

Fig. 4 (abstract P166).

TCR-transduced T cells lyse H3.3K27M+HLA-A2+ glioma cells in an HLA-A*0201- and H3.3K27M-dependent manner. Cytotoxicity of TCR-transduced T cells was evaluated by lactate dehydrogenase (LDH) cytotoxicity assay. A,B, C. TCR-transduced or mock-transduced T cells were co-cultured with H3.3K27M+HLA-A*0201+ HSJD-DIPG-017 cells, HSJD-DIPG-021 cells or control H3.3K27M+HLA-A*0201- HSJD-DIPG-019 cells at E/T ratio of 1, 5, and 10 for 24 hrs. D. TCR-transduced or control T cells were co-cultured with HLA-A*0201+ U87H3.3K27M cells or U87H3.3WT cells at E/T ratio of 5. Each group was assessed in triplicate. Data represent two independent experiments with similar results. *p

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