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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden

Fig. 3

CD8+ T-cell infiltration pattern and clinical benefits from immune checkpoint inhibition. a CD8+ T-cell infiltration pattern was assessed by a trained pathologist upon immunohistochemistry with a CD8-specific antibody. Representative images are depicted (scale bar = 500 μm or 1 mm). b, c Overall survival upon stratification based on infiltration pattern (non-infiltrated, infiltrated, excluded) for metastatic melanoma patients treated (b) prior to the introduction of ICIs (historical controls; n = 94) and (c) ICI-treated melanoma patients (n = 137). For all comparisons p > 0.05

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