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Table 1 Cytokines influenced (alteration>2folds) by AGT silence

From: Local angiotensin II contributes to tumor resistance to checkpoint immunotherapy

Cytokines Functions
Immune-activating
 IL-7 Necessary for both B-cell and T-cell proliferation [43].
 IL-20 Enhancing innate and adaptive immunity [44].
 CD40 ligand A potent dendritic cell activation molecule, counteracting immune escape mechanisms in the tumor microenvironment [45, 46].
 CXCL1 Pro-inflammatory cytokine: the activation and regulation of innate and adaptive immunity [53].
 CXCL11 Chemotactic for activated T cells [47].
 CXCL14 Attraction of dendritic cells [48]
 TNFSF14 Stimulating lymphocyte proliferation and tumor cell-specific anti-tumor immune responses [49].
Immunosuppressive
 IL-3 Promoting dendritic cells secreting significantly less IL-12 p70 and more IL-10 [54]
 IL-4 Participating in both TAM and MDSC survival and the acquisition of an immune-suppressive phenotype [55, 56].
 IL-10 Inhibiting the ability of APCs to present antigens to T cells [57]
 Fas Inducing apoptosis of cytotoxic T lymphocytes through the FAS-FASL pathway [58]
 Fas ligand (FASL) Inducing apoptosis of cytotoxic T lymphocytes through the FAS-FASL pathway [58]
 CCL1 Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege [59]
 CCL7 Chemoattracting MDSCs and Tregs in tumor microenvironment [60].
 SDF-1 Increasing immunological tolerance by polarizing Tregs [61].
 CCL28 Recruiting Tregs in tumor hypoxia microenvironment [62].
 G-CSF Recruiting MDSCs in tumor hypoxia microenvironment [63].
 GM-CSF Shaping the tumour microenvironment by promoting myelopoiesis and recruitment of suppressive myeloid cells [55, 64, 65]
 Eotaxin-2 the recruitment and polarization of Tregs [66, 67].
 TNFSF12 Curtailing the innate response and its transition to adaptive TH1 Immunity [68].