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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

Fig. 3

HLA score and CD8 positive cells combination as prognostic factor. (a) Kaplan-Meier survival analysis based on the number (low (n = 57) or high (n = 57) split at the median) of CD8 positive cells per mm2. (b) Kaplan-Meier survival analysis based on the HLA-score (low (n = 41) or high (n = 69)). (c) Correlation between HLA- score and the number of CD8 positive cells per mm2. (d) Kaplan-Meier survival analysis based on the composite variable using CD8+ cells and HLA-score (low/low in blue (n = 24), intermediate in green (n = 47), high/high in red (n = 38)) (e) Kaplan-Meier of overall survival analysis based on the composite variable CD8/HLA for WT patients (low/low in blue (n = 13), intermediate in green (n = 37), high/high in red (n = 23). (f) Kaplan-Meier of overall survival analysis based on the composite variable CD8/HLA for RAS-RAF mutated patients (low/low in dark blue (n = 11), intermediate in dark green (n = 10), high/high in dark red (n = 15). (*: p < 0.05, **: p < 0.01, ***: p < 0.001)

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