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Table 2 Overall Survival statistical summary

From: RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

Variable Total Univariate Cox models Multivariate Cox models
Clinical model Clinical and CD8 model Clinical and HLA model Clinical and HLA/CD8 model
Hratio 95% IC p adj padj padj p Hratio 95% IC p adj padj padj p Hratio 95% IC p adj padj padj p Hratio 95% IC p adj padj padj p Hratio 95% IC p adj padj padj p
Age (%) median (range) 63 (29–83) 1.015 [0.993;1.038] 0.18 0.42 1.018 [0.995;1.041] 0.13 0.36 1.012 [0.990;1.035] 0.3 0.57 1.016 [0.993;1.040] 0.17 0.42 1.015 [0.993;1.039] 0.18 0.42
continuous mean(sd) 61.73 (11.47)
Sex(%) Female 33 (28.95) 1     1     1     1     1    
  Male 81 (71.05) 0.762 [0.469;1.238] 0.27 0.55 0.77 [0.464;1.282] 0.32 0.57 0.771 [0.460;1.292] 0.32 0.57 0.759 [0.447;1.289] 0.31 0.57 0.686 [0.397;1.185] 0.18 0.42
Chemo(%) No 36 (31.58) 1     1     1     1     1    
  Yes 78 (68.42) 0.812 [0.502;1.314] 0.4 0.6 0.73 [0.432;1.231] 0.24 0.53 0.928 [0.534;1.612] 0.79 0.92 0.744 [0.438;1.262] 0.27 0.55 0.793 [0.464;1.355] 0.4 0.6
KRAS No 79 (69.30) 1    
  Yes 35 (30.70) 1.979 [1.211;3.233] 0.006 0.05
BRAF+KRAS No 76 (66.67) 1     1     1     1     1    
  Yes 38 (33.33) 1.737 [1.07;2.82] 0.03 0.13 2.06 [1.223;3.487] 0.007 0.05 2.171 [1.281;3.682] 0.004 0.05 1.882 [1.104;3.230] 0.02 0.1 1.716 [0.992;2.968] 0.05 0.2
Tumor side Right 25 (21.93) 1     1     1     1   1   1    
  Left 89 (78.07) 0.92 [0.528;1.604] 0.77 0.91 1.304 [0.721;2.359] 0.38 0.6 1.151 [0.639;2.074] 0.64 0.79 1.334 [0.735;2.421] 0.34 0.58 1.208 [0.671;2.175] 0.53 0.7
CD8 invasive margin continuous    0.66 [0.500;0.866] 0.003 0.05   0.644 [0.477;0.869] 0.004 0.05         
CD8 tumor core continuous    0.906 [0.679;1.209] 0.5 0.67              
CD8 total continuous    0.705 [0.534;0.926] 0.01 0.06              
HLA score   41 (37.27) 1          1        
   69 (62.73) 0.593 [0.366;0.959] 0.03 0.13      0.631 [0.379;1.050] 0.08 0.25     
HLA/CD8 combined Low/Low 24 (21.82) 1                 1    
  Others 86 (78.18) 0.391 [0.230;0.663] 0.0005 0.02              0.415 [0.234;0.737] 0.003 0.05
PDL1 TC SP142 High 18 1                 
  Low 5 (4.39) 0.6 [0.147;2.443] 0.48 0.66             
PDL1 invasive margin SP142 High 34 (29.82) 1                 
  Low 80 (70.18) 0.791 [0.463;1.348] 0.39 0.6             
CD163 invasive margin 1 27 (23.68) 1                 
  2 42 (36.84) 0.719 [0.408;1.266] 0.25 0.54             
  3 32 (28.07) 0.807 [0.443;1.467] 0.48 0.66             
FoxP3 invasive margin 0 45 (39.47) 1                 
  1 20 (17.54) 1.182 [0.654;2.135] 0.58 0.73             
NKp46 Low 50 (49.50) 1                    
  High 45 (50.50) 1.024 [0.640;1.636] 0.93 0.98                 
AUC 0.63 0.72 0.67 0.72