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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Fig. 1

a Schematic representation of transposon constructs used for induction of HCC contain 5′ and 3′ inverted repeats, human AKT1 (hAKT) gene, p2A linker peptide sequence (2A), firefly luciferase reporter (LUC) gene and a mini-gene encoding ploypeptides derived from ovalbumin, HBV core protein and HBV surface protein (OVA-HBc-HBs). b Experimental scheme of HCC induction and monitoring

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