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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Fig. 2

Kinetics of HCC induction in mice receiving HDI of pKT2/CLP-AKT, pT/Caggs-NRASV12 and pCMV(CAT)T7-SB100. a Livers harvested from the mice at indicated time points after HDI. Yellow arrows indicate white spots or nodules on the liver. Hematoxylin-and-eosin (H&E) staining of liver sections from b mice at day 58 post HDI with DPBS (ctrl), c mice at day 30, d mice at day 45, or e mice at day 58 post HDI with DPBS containing the three plasmids. Yellow arrows in (c) and (d) indicated fatty change regions. The yellow arrow in e indicated mononuclear infiltration near the stroma; T: tumor region, L: adjacent liver tissue; Scale bars, 1000 or 100 μm

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