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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity

Fig. 4

Performance of microsatellite instability (MSI) prediction algorithms in colorectal and endometrial/neuroendocrine cancer sample sets. Left column: colorectal samples; right column: endometrial/neuroendocrine samples. Blue points are mismatch repair (MMR)-proficient tumors; red points are MSI-H. Top row: the Hypermutation Predictor and MMR Loss scores are plotted against each other. Lines show the regions of the plot corresponding to p-value thresholds of 0.05, 0.01, and 0.001 on the MSI Predictor score, in which all points below the line would be called MSI-H. Middle row: values of the MSI Predictor score are plotted vs. microsatellite stable (MSS)/MSI-H status. The p = 0.05, 0.01, and 0.001 thresholds are indicated with horizontal lines. Bottom row: receiver operating characteristic (ROC) curves are shown for all 3 algorithms

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