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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella

Fig. 7

Graphical depiction of how intracellular accumulation could mechanistically improve tumor colonization. a) When Salmonella have a low intracellular accumulation rate, the rate of dispersion back into tumor vasculature is high, thus reducing bacterial tumor colonization due to a lack of “binding” to cancer cells. b) When Salmonella have a high intracellular accumulation rate, more bacteria would be retained in the tumor and not leak back into tumor microvasculature, thus increasing overall tumor colonization.

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