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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

Fig. 2

HMGN1 expanded CD8+ T cells in the tumor. a Flow cytometry gating of tumor-infiltrating CD8+ T cell populations. b, c The compartment, frequency, and cell number of CD8+ T cells in the tumor by using flow cytometry. d, e The compartment, frequency, and cell number of CD44hi PD-1+ CD8+ T cells in the tumor. f, g The compartment, frequency, and cell number of CD137+ PD-1+ CD8+ T cells in the tumor. Each result is representative of three independent experiments with at least four mice per group. Data are presented as mean ± SEM. *, P < 0.05, **, P < 0.01 for a dunnett’s post hoc test (compared with control); p values in the figures indicate Student’s t-test comparing mH/αCD4-treated and αCD4-treated groups

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