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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

Fig. 5

HMGN1/αCD4 treatment synergistically reduced exhausted CD8+ T cells in the tumor. a The compartment of PD-1hi, PD-1lo, PD-1 CD8+ T cells in the tumor. b The expression level of LAG-3, TIM-3, and TIGIT on PD-1hi CD8+ T cells. c The compartment and frequency of IFN-γ+ among in PD-1+ CD8+ T cells. d The compartment and frequency of IL-2+ TNF-α+ among in IFN-γ+ PD-1+ CD8+ T cells. Each result is representative of three independent experiments with at least four mice per group. Data are presented as mean ± SEM. *, P < 0.05, **, P < 0.01, ***, P < 0.001 for a dunnett’s post hoc test (compared with control); p values in the figure indicate Student’s t-test comparing mH/αCD4-treated and αCD4-treated groups. Geometric mean fluorescence intensity (GMFI)

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