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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

Fig. 6

CD8+ T cell transcriptome analysis revealed the promotion of activation after HMGN1/αCD4 treatment. a Analysis scheme of transcriptome analysis of CD8+ T cells in tumor-bearing mice. b Heatmap representation of DEGs that associated with T cell function-related significantly-enriched GO groups genes. Each column represents group, whereas each row represents an individual gene. Z-score of module groups is shown on the left bottom of the heatmap. c qPCR analysis of expression changes of PD-1(Pdcd1), TIM-3 (Havcr2), LAG-3 (Lag3), and CTLA-4(Ctla4). The expression levels of all target mRNAs were normalized against the expression level of Gapdh in each sample. Data are presented as mean ± SEM. A Student’s t-test is used to compare the statistically significant difference between mH/αCD4-treated and αCD4-treated groups

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