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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Fig. 5

ASC is expressed in situ in tumor cells and TAMs and its expression in primary tumors correlates with reduced overall survival. a-d Immunohistochemistry of ASC protein expression in representative samples of tumor and tumor surrounding tissue. a ASC staining in both the nucleus and the cytoplasm in both tumor cells and TAMs. b ASC staining in both the nucleus and the cytoplasm in tumor cells while prevalently cytoplasmic in TAMs. c ASC staining is negative in tumor cells and in TAMs is prevalently nuclear. d ASC staining in normal pancreatic tissue surrounding the tumor. e Immunofluorescence staining of ASC (green) in tumor cells and TAMs (identified by CD163 staining in red). Cells co-expressing ASC and CD163 are indicated in orange (merge). f Kaplan-Meier curves of overall survival of 178 PDAC patients grouped based on median ASC RNA expression. Significance was evaluated by the Log-rank (Mantel-Cox) test (p = 0.04)

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